Epididymo-orchitis is a condition where there is inflammation of your epididymis and testicle. The epididymis is a bundle of very small tubes found next to each testicle. The epididymis is where sperm from each testicle passes before it goes out of the penis. Epididymo-orchitis usually affects the epididymis and testicle on one side of the scrotum, but it may affect both sides.



  • Antibiotics: This medicine is given if epididymo-orchitis was caused by a bacterial infection. Take them as directed.
  • NSAIDs: These medicines decrease swelling, pain, and fever. NSAIDs are available without a doctor’s order. Ask which medicine is right for you and how much to take. Take as directed. NSAIDs can cause stomach bleeding or kidney problems if not taken correctly.
  • Pain medicine: You may be given a prescription medicine to decrease pain. Do not wait until the pain is severe before you take this medicine.
  • Take your medicine as directed. Call your healthcare provider if you think your medicine is not helping or if you have side effects. Tell him if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take. Include the amounts, and when and why you take them. Bring the list or the pill bottles to follow-up visits. Carry your medicine list with you in case of an emergency.

Follow up with your primary healthcare provider or urologist as directed:

You may need to return for blood tests or other testing after you are done with treatment. Write down your questions so you remember to ask them during your visits.


  • Ice: Ice helps decrease swelling and pain. Ice may also help prevent tissue damage. Use an ice pack or put crushed ice in a plastic bag. Cover it with a towel and place it on your swollen testicle or scrotum for 15 to 20 minutes every hour as directed.
  • Rest: Rest or decreased activity may help decrease your pain. It may also help you heal faster. Return to normal activities as directed.
  • Safe sex: Use a latex condom during oral, vaginal, or anal sex. Do not have sex with someone who has a sexually transmitted infection (STI). If you have an infection, let your sexual partner know so they can be checked for an STI and treated if needed. Do not have sex while you or your partner is being treated for an STI, or until your primary healthcare provider says that it is okay.
  • Scrotal support: You may be told to put a pillow or rolled up towel under your scrotum to elevate your scrotum when you lie down or sit. This may help reduce your pain. An athletic supporter may make you more comfortable when you stand.

Contact your primary healthcare provider or urologist if:

  • You have a fever.
  • You have chills or feel weak and achy.
  • Your pain is not relieved by bed rest, applying cold, or scrotal support.
  • You have questions or concerns about your condition or care.

Seek care immediately or call 911 if:

  • You have an area of redness, swelling, and increased pain in your scrotum.
  • You develop severe pain in your testicle.